This policy paper seeks to discuss how ASEAN can better deal with political and humanitarian crisis in Myanmar after the February 2021 Coup, especially in 2022 during Cambodia’s ASEAN Chairmanship. It specifically discusses how ASEAN with a Cambodia’s Chairmanship should and may translate the Five-Points Consensus agreed by the ASEAN Leaders in the 2021 Jakarta Summit. In so doing, this paper discusses about significance of addressing the crisis for Cambodia as the 2022 ASEAN Chair, including its inherent capacities as well as challenges that Cambodia may face to play a more significant role in dealing with the crisis. This paper will then lay out some elements to make a better strategy and some practical recommendations. Cambodia's upper hand in dealing with the crisis is related to its position in the sub-regional of Mekong in Southeast Asia and its relations with regional powers. Its history of dealing with an internal crisis and a war with Vietnam, experience as a benefactor of an ASEAN peace process, and the Prime Minister Hun Sen personal factor might constitute Cambodia's capacities as an effective Chair to bring more solutions. This paper also shows that lag in ASEAN responses in the past and humanitarian situation on the ground of Myanmar today challenge’s Cambodia as well as ASEAN role in dealing with the crisis. If Cambodia chooses to rely on quiet and back-door diplomacy, Cambodia should work with close consultation with its regional peers, especially since longer-term solution requires supports and resources that can only possible with supports from within and outside ASEAN. By considering both capacities and challenges, this paper proposes that Cambodia should lead ASEAN to define and institutionalize the mandate of the ASEAN Five Points Consensus by establishing an ASEAN Office on Myanmar. Taking into account that dealing with crisis requires a longer-term plan and strategy, this paper recommends that to realize such objective, ASEAN should work closely with supports from track 1.5, its regional counterparts, as well as the United States, to make the most benefits of its existing mechanism and agencies.